Pathology of Fatigue

Understanding Fatigue: Insights from the “Testing for Fatigue” Webinar

The Testing for Fatigue webinar addresses one of the most commonly reported symptoms in healthcare: fatigue. This session aims to guide clinicians in identifying the root causes of fatigue and determining which tests to run to uncover underlying issues, thereby supporting more targeted treatment plans.

Defining Fatigue and Its Impact

We begin by defining fatigue and exploring who is most affected by it and when it becomes clinically significant. Fatigue is more than just tiredness; it can be a chronic and debilitating condition that affects both physical and mental health. The webinar discusses potential causes, ranging from pharmaceutical side effects to organic and lifestyle factors. Tools for assessing fatigue severity, including standardised questionnaires and physical examinations, are also introduced.

Comprehensive Diagnostic Testing

1. Nutrient Deficiency Testing

• Iron Studies: Assessing iron levels to rule out iron deficiency anaemia.
• Vitamin B12: Including active B12 and methylmalonic acid to evaluate B12 deficiency.
• Folate Levels: RBC folate testing to assess cellular folate levels.
• Vitamin D: Measuring vitamin D levels to identify deficiencies impacting energy and immunity.

2. Thyroid Function Testing

• Key Markers: TSH, T4, T3, and reverse T3 levels for a full thyroid health assessment.
• Testing Methods: Both blood and spot tests are discussed for a comprehensive evaluation.

3. Hormonal Testing

• Cortisol and DHEA-S: Measuring these stress hormones to evaluate adrenal function.
• Melatonin: Assessing levels to understand circadian rhythm disruptions.
• Testing Options: Blood, urine, and saliva testing provide a well-rounded view of hormonal health.

Empowering Clinicians with a Systematic Approach

With these insights, participants will gain a systematic approach to identifying the causes of fatigue and tailoring interventions that address the individual needs of each patient. By combining comprehensive testing with clinical expertise, clinicians can better support patients struggling with this pervasive symptom.